State-of-the-art instrumentation.

Nanoparticle tracking analysis system that measures particle size distribution and concentration using light scattering and Brownian motion. Provides reliable, reproducible quantification of EVs in complex biological fluids.

Dual-laser nanoparticle tracking analyser adding direct zeta potential measurement and dual-channel fluorescence to size and concentration analysis — measured in-cell, with no disposables. Ideal for orthogonal sizing and colloidal-stability assessment of EV preparations.

Benchtop super-resolution microscope enabling direct stochastic optical reconstruction microscopy (dSTORM). Provides single-molecule localisation imaging for nanoscale morphological assessment of EVs and their surface markers at sub-20 nm precision.

High-resolution fractionation system coupled to multi-angle light scattering (MALS), UV (Shimadzu SPD-M20A), and fluorescence (Agilent Infinity 1260) detectors. Separates and characterises EVs, liposomes, LNPs, and viral particles by size without a stationary phase.

High-performance preparative ultracentrifuge for differential and density gradient ultracentrifugation of EVs. Equipped with SW32.1 and SW55 rotors for processing a wide range of sample volumes.

High-speed centrifuge for pre-clearing complex biological samples and pelleting large EVs and cell debris. Essential first step in multi-step EV isolation workflows from serum, plasma, urine and conditioned media.

Refrigerated benchtop centrifuge for routine EV sample preparation. Three units available for concurrent processing, ensuring throughput and flexibility across simultaneous user projects.

Automated high-throughput fraction collector for EV isolation via SEC columns. Runs up to 8 columns simultaneously with programmable fraction collection, high-precision optical drop detection, and Column Saver to prevent columns drying out between runs.

Laboratory automation workstation for robot-assisted density gradient preparation and fraction collection. Features 12 deck positions, liquid-level sensing pipetting (1–1000 µL), and a positive-pressure HEPA enclosure for sterility. Operated with a custom-made script for EV density gradient workflows.